pluripotent stem cells give rise to different stem cell lineages.

oncogenic mutations occur in pluripotent stem cells, which then differentiate to myeloid or lymphoid lineages

Mutations can cause:

• increased cell division (JAK2, MYC translocations activating tyrosine kinase)
• decreased apoptosis (BCL2 translocation)
• increased self renewal (MLL translocation, PML-RARA fusion gene)

Myeloid Neoplasms

Lymphatic Neoplasms

Leukemia

Tumour Lysis Syndrome (TLS)