• Lymphoid Neoplasms (Leukemia + Lymphoma)

Aetiology

• Idiopathic
• Infective (EBV)
• Genetic

Pathogenesis (common B cell neoplasms)

• Overexpression of anti-apoptotic oncogene
• Loss of growth control (BCL2) → Neoplasm
• abnormality at different stages of development results in differing lymphoma/leukemia. Commonest is germinal centre B Cell (capable of producing ABs)

Classification

complex and controversial

4 major groups:

Hodgkin's Lymphoma

• Neoplasia of B Lymphocytes. (Reed Sternberg cells)
• 6%