-osis

• small stiff lungs
• decreased elastic recoil
• decreased FEV, FVC and TLV

Pathophysiology

1. type II pneumocyte hyperplasia
2. TH2 lymphocyte response
3. Growth factors TGF beta, FGF
4. interstitial accumulation of lymphocytes
5. Interstitial fibrosis

• marked thickening of of alveolar septa
• chronic fibrosis/inflammation

Classification

• Interstitial Lung Disorders:

  • Fibrosis

    Idiopathic Pulmonary Fibrosis (IPF)

    Pneumoconiosis (coal miners/workers pneumoconiosis)

    Silicosis

    Asbestosis

  • TB, Sarcoidosis.

  • Hypersensitivity pneumonitis (allergic alvolitis)

  • Eosiniophilic:

  • Smoking related

• Extrinsic Disorders (chest wall):
  • Kyphosis, Obesity(Pickwick sy).
  • Pleurisy, rib fracture etc.
  • Paralysis/weakness of resp. muscles

Diffuse parenchymal