crystalline hydrated silicates with Protein & Hemosiderin coating = Asbestos bodies.

Pathophysiology

Macrophage → inflammation → Fibrosis.

• Interstitial fibrosis: Asbestosis

• Pleural effusion, fibrous pleural plaques*

• Diffuse fibrosis & Honeycombing.

• Pleural Mesothelioma, Lung & Laryngeal Carcinoma.

  

Clinical Features

• Dyspnoea, dry cough, Clubbing in 50%.

Risk Factors

Smoking + Asbestos → increased ca*