Exo and Endocrine (1-2%) gland

has head, body and tail supplied by portal circ

lytic but inactive proenzymes activated by trypsin in duodenum

acini secrete trypsin inhibitors in the pancreas

Anatomy

• behind stomach
• retroperitoneal
• majority exocrine - acini cells secrete digestive enzymes in inactive form into interlobar ducts to duodenum
• endocrine (insulin, glucagon, alpha delta cells) clusters of endocrine cells within endocrine gland (islet of langerhans)

Disorders

Congenital: divisum, annular, ectopic

Pancreatitis

Pancreatic Tumours/Cancer