Stroke

stroke: Acute neurological deficit: Clinical

“CVA” Cerebro-Vascular Accident: cause: Pathology.

Fun facts

• Neurons “Aerobic”: Continuous O2 need. ~10 min of ischemia - irreversible injury.
• Brain ~2% of body wt. | ~20% of cardiac output | ~20% body O2
• deep branches of MCA most common (basal ganglia: thalamus, internal capsule, globus pallidus) → hemiplagia
• Umbra: Area of permanent cell death from infarct
• penumbra: area of temporary inflammation surrounding infract → possibility of recovery

Global ischemia

Stroke types:

Clinical

• Transient Ischemic Attack: Resolve <24h, No cell death.
• Evolving: Increasing (Thrombotic) Atheroma → thrombosis.
• Completed: (Embolic) no change.

Pathological