definition

within 30days of surgery in absence of prosthesis

within year in presence of prosthesis

superficial: skin and subcut

deep: fascia, orgna space

ABx prophylaxis

additional doses may be indicated in procedures >4hrs

peak ABx concentration at time of incision

SIRS

temp more than 38 or less than 26

resp <20 or PAcO2 <32

pulse >90

WCC >12 or <4 or band cells >10%

pancreatitis classic example of SIRS: attack of pancreatitis, then systemic components occur due to loss of inflammatory regulation