• Amitriptyline
• Amoxapine
• clomipramine
• desipromine
• Imipramine
• Nortriptyline

<aside> 💡 care for glaucoma, urinary retention, famHx QTc prolongation, MOAI, SSRI, hepatic injury

</aside>

Indication: Depression, GAD, PTSD, OCD, neuropathic pain, insomnia, migraine

MOA: inhibit SERT and NET (different levels of selectivity per drug) → increased 5-HT and noradrenaline in synapse.

also inhibit histamine, alpha, and muscarinic receptors (likely not therapeutic, but side effects)

Dose/Route/Frequency

Side Effect

• insomnia