zide/-ide

MOA

• Bind to the sulfonylurea receptor on plasma membrane of beta cells → inhibits ATP-sensitive K+ channels → reduced efflux of K+ resultant evokes depolarisation which opens voltage-dependent Ca2+ channels → increased free cytosolic calcium levels → insulin secretion and a decrease in blood glucose
• Also inhibits glucagon secretion and sensitize target tissues to the action of insulin
• Can kill pancreas
• TLDR: increase pancreatic insulin secretion and decrease insulin resistance

indication

Type 2 diabetes

Contraindication

• Ketoacidosis
• Type 1 diabetes

Route

Oral

Frequency