• Venlafaxine (Effexor)
• Duloxetine (Cymbalta)
• Desvenlafaxine (Pristiq)
• Levomilnacipran (Fetzima)

Indication: Depression, GAD, PTSD, OCD, neuropathic pain

MOA: inhibit SERT and NET → increased 5-HT and noradrenaline in synapse

Dose/Route/Frequency

Side Effect

• insomnia
• anxiety
• irritability
• sexual dysfunction
• Nausea, vomiting, diarrhoea
• may increase BP and heart rate