pyramids place of DCT, CD, loop of henle. Glomeruli in cortex renal papilla most distal part of nephron

any block in glomerulus impacts blood supply of entire nephron (atrophy)

DCT has flatter cells, thinner pct has big, enzymatically active cells, more ER activity

be able to label

glomerular structure facilitates plasma filtration inner most layer: fenestrated endothelium prevents cell escape basement membrane: stops larger proteins (globlins) outer podocytes with foot processes stops smallest proteins (albumin)

minor damage damages only podocytes - only albumin escapes → hypoalbuminaemia

severe damage damages all layers → blood, protein, cells escape. oliguria from inflammation blocking capillaries