typical last choice due to drug-drug interaction and drug food interactions

• Phenelzine (Nardil)
• Tranylcypromine (Parnate)
• Isocarboxazid (Marplan)
• Selegiline selective for MAO-B and used in Parkinson's

Indication: Depression, panic disorder, Parkinsons

MOA: irreversible inhibition of inhibit MAO-A and -B → decreased 5-HT degradation and increased availability

Dose/Route/Frequency

Side Effect

• prevents metabolism of tyramine in aged or fermented food products → ++ catecholamine release → hypertensive crisis → stroke (cheese reaction meme)