<aside> 💡 children <16 years, arthritis for >6 weeks without obvious cause

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3 major subtypes:

• Oligoarthritis
• Polyarthritis
• Still’s disease (severe systemic with massive splenomegally but little arthritis)

Demographics

1/1000 children

Pathology

• HLA & PTPN22, & Inflammation - same as RA.

Clinical Features

• Predominantly systemic involvement unlike RA.
• Fever, Uveitis, splenomegaly. No RA nodules.
• Oligoarthritis (few joints), large joints more affected than small joints
• ANA Positive but RF & Anti CCP –ve (Seronegative)

Differential Diagnosis

• Septic arthritis, Osteomyelitis, Trauma, Tumours.
• ARF, IBD, Henoch Schonlein purpura, SLE,