75% of anterior pituitary loss, & or with posterior pituitary loss

• Combined anterior & posterior (D insipidus) → hypothalamic disorders (tumours)
• Congenital, Acquired (tumors, injury, necrosis). “Empty sella Syndrome”
• Craniopharyngioma (tumour of epithelium from Rathke’s pouch) or Glioma.
• Clinical features based on the hormone involved.
  • GH: Pituitary dwarfism (proportional)
  • FSH/LH: Infertility, impotence
  • TSH: Hypothyroidism
  • MSH: Pallor (melanocytes)
  • ACTH: Hypo-adrenalism.
  • Post. Pituitary loss leads to D.insipidus.