Congenital

Lack of Ganglions in terminal rectum → loss of motility

narrowing (not responding to peristalsis) → dilation of normal proximal segment → intestinal obstruction

• Males 4:1
• Mild (infancy) or Severe (at birth)
• Constipation, vomiting & diarrhoea.

Complications

• secondary enterocolitis
• fluid and electrolyte disturbances.

Acquired Megacolon

same condition but from following causes with normal ganglia

• Inflam
• Strictures,
• Toxic in Ulcerative Colitis
• Chaga’s disease: Trypanosoma cruzi (South America paracyte) loss of ganglia. common in oesophagus