Commonest,

Aetiology

Oropharynx(HSV-1) or Genitals (HSV-2).

Clinical features

• ulcerated vesicular rash.
• Self limited cold sores 1-2wks
• can be severe in immunocompromised.
  • Herpes keratitis (blindness) hepatitis, pneumonia, esophagitis, encephalitis etc.

Pathology

• Spread via sensory axons → neuron cell body – latency*.

Microscopy: Multinucleated giant cells with viral inclusions. (Tzanck smear)