<aside> 💡 if cirrhosis or ATSI >50, screen every 6 months for serum alpha fetoprotein (AFP) and USS to check for HCC

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Aetiology

• often from cirrhosis
• can be secondary to viral infection; Hep B/C and Aflatoxin (fungal food toxin from aspergillus flavus on grains, eaten by cows, toxin passed in milk.)

Demographics

• People that have risk factors → increased alcohol use, Hepatitis infections etc
• It is estimated that 2832 people will be diagnosed with liver cancer in Australia in 2021.
• Men are three times as likely to be diagnosed as women.
• usually occurs in 50% (asia) - 90% (western) cirrhosis
• increasing incidence in asia due to toxins
• increasing in western world due to increased HCV HBV

Risk factors

• Cirrhosis
• HBV
• HCV
• Fatty liver disease