Demographics
Risk factors again
Pathophysiology
Sexual (75%), blood/blood products (transfusion, IVDU), vertical (mum to baby), oral transmission of virus -> HIV infection -> Insert into host genome and replicate, (asymptomatic/flu like for weeks in acute phase). Virus titre increases -> budding and virion release. CD8 cells target and deplete CD4 cells over years. Eventual CD4 depletion leads to AIDS, opportunistic infection and death
risk factors
clinical features
Acute retroviral syndrome/seroconversion illness 2-4w up to 10m