End stage of many diffuse liver damages resulting in scaring and regenerating nodules.

shrunken and nodular gross appearance

Demographics

• Male
• 50-60yo
• Low SES

Commonest Causes

• Hepatotoxicity (Alcohol) 60-70%

• Inflammation (Viral, autoimmune, PBC, PSC) 10%

• Cryptogenic 10-15% *

• Biliary disorders 5-10%

• metabolic disorders (Hemochromatosis, NAFLD) 5%

• Pathophysiology

• Clinical features