Neurological multisystem disease of excess exhaustion. Deterioration of health in a previously healthy person.

• Unknown etiology: ? Viral, ? Immune, ? Pollution.
• Epidemiology: Common, any age, females more.

Symptoms

• chronic (>6m) Fatigue, post exercise fatigue*, sleep dysfunction, non specific myalgic pain,

• Neurological: confusion, disorientation, sensory disturbances, ataxia, muscle weakness, photophobia, emotional, anxiety. Etc.

• Autonomic & neuroendocrine manifestations: sweating, low body temp. cold extremities, cold/heat intolerance. Weight change. Anorexia.

• Diagnosis: by exclusion.

• Prognosis: poor <10% return to normal health. Better in children & youth.

• Differentials: Endocrine, RS, CVS, anemia, DM, depression* etc.