Peripheral neuropathy caused by compression of the median nerve by the transverse carpal ligament
demographics: women, 40-50yo
Pathophysiology
- compression of the median nerve: inflammation of the nearby tendons/ tissues → inflamm → oedema → compression
Risk Factors
- Previous fracture of the distal radius (most important risk factor)
- Traumatic dislocation of the lunate
- Manual work: increased risk in workers using vibrating tools or prolonged, forceful, and repetitive flexion/extension of the wrist à such as typer, cacrpetnder, driver etc
- Rheumatoid arthritis and other types of chronic inflammation of the tendon sheaths
- Pregnancy and puerperium
- Obesity
- Osteoarthritis
- Systemic amyloidosis
- Renal failure: due to dialysis-associated deposition of amyloid