Rare cancer that originates within the mucosal (glandular) lining of the gallbladder. Adenocarcinoma commonest.

• Late diagnosis, Poor prognosis.
• Commonly diagnosed incidentally after cholecystectomy

demographics: 50-70yo, Females , Hispanics

Risk Factors

• Cholelithiasis.
• Chronic cholecystitis.
• Porcelain gallbladder (calcified and fibrotic gallbladder).
• Gallbladder polyps.
• Chronic infection (i.e. salmonella typhi).

Clinical Features

Most gallbladder cancers arise within the fundus.

Initially asymptomatic.

• Non-specific symptoms (i.e. malaise, fatigue, nausea, vomiting, weight loss/anorexia).