dihydropyridines - amploDIPINE

non-dihydropyridines - diltiazem/verapamil (cardiac specific)

MOA

• Inhibit influx of Ca2+ via L-type VGCC, normally causing contraction
• Variety of hypotensive effects depending on the subclass and location of calcium channels inhibited
  • Dihydropyridines act predominantly as vasodilators with little cardiac effects
  • Non-dihydropyridines vasodilate but also inhibit AV node conduction and reduce cardiac contractility (reducing DAD/EAD to suppress premature ectopic beats)

Indication: HTN and angina

Contraindications: contraindicated in systolic HF, hypotension, severe angina

<aside> 💡 non dihydropyridines metabolised by and can inhibit CYP3A4/5

</aside>

Side effects: palpitations, headache, flushing