Demographics:

• rare

Pathology:

• genetic mutation in A1AT ⇢ hepatocyte accumulation of A1AT ⇢ fibrosis

Risk Factors

• FHx

Presentation

• COPD, hepatitis ⇢ cirrhosis

Investigations

• LFT: ⇡AST+ALT
• Spirometry: obstruction without reversibility
• Alpha1 antitrypsin levels decreased